Bus Tickets from Santa Clara, US to San Luis Obispo

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TomorrowJun 22
from US$76
MonJun 23
from US$76
TueJun 24
from US$76
WedJun 25
from US$76
ThuJun 26
from US$76
FriJun 27
from US$76
SatJun 28
SunJun 29

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: June 22 at
    Departure city: Santa Clara
    Departure location: Santa Ana Regional Transportation Center
    Arrival time: June 23 at
    Destination city: San Luis Obispo
    Destination location: AMTRAK Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: June 22 at
    Departure city: Santa Clara
    Departure location: Santa Ana Regional Transportation Center
    Arrival time: June 23 at
    Destination city: San Luis Obispo
    Destination location: Cal Poly Vista Grande Dining Complex
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

Last refresh of the prices: Last Tuesday at 4:31 PM PDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Santa Clara to San Luis Obispo

Bus
Average PriceUS$76 - US$76Average Duration10h 45m
8kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average PriceUS$49 - US$49Average Duration6h 45m
28kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from Santa Clara to San Luis Obispo

Among the sustainable travel choices, the train stands out as a good way to reach San Luis Obispo. The journey takes about 6 hours 45 minutes, and with fares starting at just US$49, it presents an excellent value for a comfortable ride.

2train per day
6h 45mAverage Duration
US$49Cheapest ticket
28kgCO₂ emissions

Bus Santa Clara to San Luis Obispo: Trip Overview

Average Ticket PriceUS$76
Average Bus Trip Duration10h 45m
Number of daily buses2
Earliest bus departure11:30pm
Distance309 km

Santa Clara to San Luis Obispo Bus

Busbud helps you find a bus from Santa Clara to San Luis Obispo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Santa Clara to San Luis Obispo will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Santa Clara to San Luis Obispo, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Santa Clara, US - San Luis Obispo

  1. What is the travel distance from Santa Clara to San Luis Obispo?

    It's about 264 km (164 miles) from Santa Clara to San Luis Obispo.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-19
US$72
06-20
US$72
Today
US$72
06-22
US$72
06-23
US$72
06-24
US$72
06-25
US$72
06-26
US$72
busbud logoThe cheapest trip from Santa Clara to San Luis Obispo was searched and found on Jun 19, 2025 with a price of US$72

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Clara to San Luis Obispo, as early as possible.

You can expect to pay from US$72 to US$72 for a bus ticket from Santa Clara to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at US$72 which is on 2025-06-22.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Santa Clara and San Luis Obispo!

Much more than a mere vehicle taking you from Santa Clara to San Luis Obispo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santa Clara to San Luis Obispo that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Santa Clara to San Luis Obispo, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Santa Clara by bus?

Bus from Santa Clara to San Luis Obispo

You can also go to San Luis Obispo by train

Train from Santa Clara to San Luis Obispo

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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