Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Durham Station | Chicago (Union Station), IL | Cheapest | ||||
| Train | Durham Station | Chicago (Union Station), IL | Fastest | ||||
| Train | Durham Station | Chicago (Union Station), IL | No tags | ||||
| Train | Durham Station | Chicago (Union Station), IL | No tags | ||||
| Train | Durham Station | Chicago (Union Station), IL | No tags |
Last refresh of the prices: Yesterday at 11:01 AM EDT.
Compare 2 ways to go from Durham to Chicago
Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 1 day, 2 hours 20 minutes and with fares starting at just $94, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5776 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $187
Frequently asked questions about traveling from Durham, NC, US to Chicago by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Durham to Chicago?
The cheapest train tickets from Durham to Chicago start from $187. The average price for this train route is around $299. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Durham to Chicago?
The average train ride duration from Durham to Chicago is 1d 15h, covering a distance of 619 miles (999 km). The quickest train can get you there in 1d 13h and is operated by Amtrak.
Which train operators service the Durham to Chicago route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Durham to Chicago?
The earliest train departs from Durham to Chicago at 6:04pm. And the latest train departs at 7:58pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Chicago was searched and found on Mar 28, 2026 with a price of $159To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Durham, NC, US to Chicago, as early as possible.
You can expect to pay from $159 to $1,233 for a train ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $159 which is on 2026-03-28.
