Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Winston Salem Greyhound Bus Station | Harrisburg Bus Station | CheapestFastest | ||||
| Bus | Winston Salem Greyhound Bus Station | Harrisburg Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Winston Salem Greyhound Bus Station | Harrisburg Bus Station | No tags |
Last refresh of the prices: Today at 3:17 AM EST.
Get from Winston-Salem to Harrisburg
The journey takes about 19 hours 40 minutes and with fares starting at just $105, it presents an excellent value for a comfortable ride.
Where are the popular stops in Winston-Salem and Harrisburg?
Stops in Winston-Salem
- A
Winston Salem Greyhound Bus Station
100 W 5th St, Winston Salem, NC 27101 - B
E Sprague St
841 E Sprague St, Winston-Salem, NC 27107, USA - C
Winston-Salem Bus Stop
2500 Old Lexington Rd, Winston-Salem, NC 27107, USA - D
1237 Silas Creek Pkwy
1237 Silas Creek Pkwy., Winston-Salem, NC 27127 (Hong Kong King Buffet)
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Winston-Salem to Harrisburg by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Winston-Salem to Harrisburg?
The cheapest bus tickets from Winston-Salem to Harrisburg start from $105. The average price for this route is around $154. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Winston-Salem to Harrisburg?
The average bus trip duration from Winston-Salem to Harrisburg is 19h 40m, covering a distance of 341 miles (549 km). The quickest bus can get you there in 19h 15m and is operated by Greyhound.
Which bus companies service the Winston-Salem to Harrisburg route?
Several major train operators operate on this route with 3 trains available per day.
What is the earliest and latest departure time for the bus from Winston-Salem to Harrisburg?
The earliest bus departs from Winston-Salem to Harrisburg at 7:10am. And the latest bus departs at 6:15pm.
What are the CO₂ emissions for the bus trip from Winston-Salem to Harrisburg?
A bus trip from Winston-Salem to Harrisburg generates an estimated 14 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Winston-Salem to Harrisburg was searched and found on Jan 21, 2026 with a price of $183To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Winston-Salem to Harrisburg, as early as possible.
You can expect to pay from $183 to $184 for a bus ticket from Winston-Salem to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $183 which is on 2026-01-21.
