Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | WJW Investments Bus Stop | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Gateway Station | WJW Investments Bus Stop | No tags |
Last refresh of the prices: Last Tuesday at 12:17 AM CST.
Get from St. Louis to Lexington
The journey takes about 12 hours and with fares starting at just $63, it presents an excellent value for a comfortable ride.
Where are the popular stops in St. Louis and Lexington?
Stops in Lexington
- A477 W New Circle Rd, Lexington, KY 40511
- B1801 Alexandria Dr, Lexington, KY 40504, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound St. Louis Lexington recent customer reviews
They wouldn’t help me and my clothes and bags are still on the bus and I’m trying to get my bags from bud in new york
Guy J.
Frequently asked questions about traveling from St. Louis to Lexington, KY by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to Lexington?
The cheapest bus tickets from St. Louis to Lexington start from $63. The average price for this route is around $109. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to Lexington?
The average bus trip duration from St. Louis to Lexington is 12h, covering a distance of 312 miles (503 km). The quickest bus can get you there in 8h 45m and is operated by Greyhound.
Which bus companies service the St. Louis to Lexington route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from St. Louis to Lexington?
The earliest bus departs from St. Louis to Lexington at 2:00am. And the latest bus departs at 4:00pm.
What are the CO₂ emissions for the bus trip from St. Louis to Lexington?
A bus trip from St. Louis to Lexington generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Lexington, KY was searched and found on Jan 15, 2026 with a price of $59To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Lexington, KY, as early as possible.
You can expect to pay from $59 to $87 for a bus ticket from St. Louis to Lexington, KY based on the last 2 days. You can expect to find the cheapest price for the trip at $62 which is on 2026-01-22.
