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- This trip is recommended because it is: Cheapest
- This trip is recommended because it is: FastestDeparture time: June 23 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 25 atDestination city: San FranciscoDestination location: San Francisco Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: June 23 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 25 atDestination city: San FranciscoDestination location: San Francisco Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: June 23 atDeparture city: St LouisDeparture location: Gateway StationArrival time: June 25 atDestination city: San FranciscoDestination location: San Francisco Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
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Compare 2 ways to go from St Louis to San Francisco.
Busbud recommends taking the bus from St Louis to San FranciscoAmong the sustainable travel choices, the bus stands out as the good way to reach San Francisco. The journey takes about 2 days, 1 hour 5 minutes and with fares starting at just $150, it presents an excellent value for a comfortable ride.
Bus St Louis to San Francisco: Trip Overview
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St Louis to San Francisco Bus
With Busbud, comparing and booking tickets for a bus from St Louis to San Francisco is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from St Louis to San Francisco from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses traveling from St Louis to San Francisco, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in St Louis and San Francisco?
Frequently asked questions for your trip St Louis - San Francisco, US
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St Louis to San Francisco was searched and found on Jun 22, 2025 with a price of $142To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to San Francisco, as early as possible.
You can expect to pay from $142 to $253 for a bus ticket from St Louis to San Francisco based on the last 2 days. You can expect to find the cheapest price for the trip at $142 which is on 2025-06-22.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from St Louis to San Francisco.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from St Louis to San Francisco, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St Louis to San Francisco that are otherwise impossible to come by with a plane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St Louis to San Francisco.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
What's the cheapest way to go from St Louis to San Francisco?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular Buses Connecting St Louis
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Buses Going to St Louis
- Bus from Manchester to St Louis
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Popular Buses Connecting San Francisco
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Buses Going to San Francisco
- Bus from Petaluma to San Francisco
- Bus Monroe - San Francisco
- San Diego - San Francisco
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- Bus Yosemite National Park - San Francisco
- Monterey - San Francisco
- Bus from Las Vegas to San Francisco