Bus Tickets from San Francisco, US to St Louis

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TodayJun 21
TomorrowJun 22
from $239
MonJun 23
TueJun 24
WedJun 25
ThuJun 26
FriJun 27
from $178
SatJun 28

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 22 at
    Departure city: San Francisco
    Departure location: San Francisco Bus Station
    Arrival time: June 25 at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 22 at
    Departure city: San Francisco
    Departure location: San Francisco Bus Station
    Arrival time: June 24 at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 22 at
    Departure city: San Francisco
    Departure location: 409 Townsend St, SF
    Arrival time: June 24 at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 22 at
    Departure city: San Francisco
    Departure location: San Francisco Bus Station
    Arrival time: June 24 at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 22 at
    Departure city: San Francisco
    Departure location: 409 Townsend St, SF
    Arrival time: June 24 at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus San Francisco to St Louis: Trip Overview

Average ticket price$332
Average bus trip duration2d 6h
Number of daily buses6
Earliest bus departure7:45am
Distance1736 miles (2800 km)
Latest bus departure11:25pm

San Francisco to St Louis Bus

With Busbud, comparing and booking tickets for a bus from San Francisco to St Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Francisco to St Louis.

Discover how much the bus trip from San Francisco to St Louis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Francisco, US - St Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/19
No data
06/20
$305
Today
No data
06/22
$231
06/23
No data
06/24
No data
06/25
No data
06/26
No data
busbud logoThe cheapest trip from San Francisco to St Louis was searched and found on Jun 22, 2025 with a price of $231

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco to St Louis, as early as possible.

You can expect to pay from $231 to $328 for a bus ticket from San Francisco to St Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $231 which is on 2025-06-22.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Francisco to St Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from San Francisco to St Louis.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Francisco to St Louis will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Francisco to St Louis.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Francisco by bus?

Bus from San Francisco to St Louis

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