Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | City of Portland | Gateway Station | CheapestFastest | |||||
 | Portland Transportation Center | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 3:49 PM EST.
Compare 2 ways to go from Portland to St. Louis
Among the sustainable travel choices, the Bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 10 hours 40 minutes and with fares starting at just $171, it presents an excellent value for a comfortable ride.
Where are the popular stops in Portland and St. Louis?
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Frequently asked questions about traveling from Portland, ME to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Portland to St. Louis?
The cheapest bus tickets from Portland to St. Louis start from $171. The average price for this route is around $238. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Portland to St. Louis?
The average bus trip duration from Portland to St. Louis is 1d 10h, covering a distance of 1088 miles (1755 km). The quickest bus can get you there in 1d 10h and is operated by Amtrak.
Which bus companies service the Portland to St. Louis route?
What is the earliest and latest departure time for the bus from Portland to St. Louis?
The earliest bus departs from Portland to St. Louis at 1:45pm. And the latest bus departs at 1:45pm.
What are the CO₂ emissions for the bus trip from Portland to St. Louis?
A bus trip from Portland to St. Louis generates an estimated 44 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Portland to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5696 reviews.
Which bus company has the best Wi-Fi from Portland to St. Louis?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company has the most timely service from Portland to St. Louis?
According to Busbud traveller reviews, the most timely bus company on this route is Amtrak, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from Portland to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Portland, ME to St. Louis was searched and found on Jan 12, 2026 with a price of $130To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Portland, ME to St. Louis, as early as possible.
You can expect to pay from $130 to $1,293 for a bus ticket from Portland, ME to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $130 which is on 2026-01-12.
What's the cheapest way to go from Portland, ME to St. Louis?
The Bus is the cheapest travel choice for this destination
