Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Mitchell MKE Airport | Knoxville Bus Station | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Mitchell MKE Airport | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Goerke's Corners Park & Ride (Brookfield) | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 7:08 PM CST.
Get from Milwaukee to Knoxville
The journey takes about 1 day, 2 hours 15 minutes and with fares starting at just $158, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milwaukee and Knoxville?
Stops in Milwaukee
- B433 W St Paul Ave, Milwaukee, WI 53203, USA
- C
S Cesar Chavez
1016 S Cesar E Chavez Dr, Milwaukee, WI 53204, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Milwaukee to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Milwaukee to Knoxville?
The cheapest bus tickets from Milwaukee to Knoxville start from $158. The average price for this route is around $166. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Milwaukee to Knoxville?
The average bus trip duration from Milwaukee to Knoxville is 1d 2h, covering a distance of 525 miles (847 km). The quickest bus can get you there in 18h 20m and is operated by Greyhound.
Which bus companies service the Milwaukee to Knoxville route?
Several major train operators operate on this route with 6 trains available per day.
What is the earliest and latest departure time for the bus from Milwaukee to Knoxville?
The earliest bus departs from Milwaukee to Knoxville at 3:20am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from Milwaukee to Knoxville?
A bus trip from Milwaukee to Knoxville generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milwaukee to Knoxville, TN was searched and found on Jan 10, 2026 with a price of $154To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to Knoxville, TN, as early as possible.
