Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mesa Bus Stop | Indianapolis Bus Station | CheapestFastest | ||||
| Bus | Mesa Bus Stop | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Downtown Transit Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Downtown Transit Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Indianapolis Northeast | No tags |
Last refresh of the prices: Last Saturday at 11:02 AM MST.
Get from Mesa to Indianapolis
The journey takes about 1 day, 21 hours 45 minutes and with fares starting at just $301, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and Indianapolis?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Mesa to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mesa to Indianapolis?
The cheapest bus tickets from Mesa to Indianapolis start from $301. The average price for this route is around $355. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mesa to Indianapolis?
The average bus trip duration from Mesa to Indianapolis is 1d 21h, covering a distance of 1483 miles (2392 km). The quickest bus can get you there in 1d 15h and is operated by Greyhound.
Which bus companies service the Mesa to Indianapolis route?
Several major train operators operate on this route with 5 trains available per day.
What is the earliest and latest departure time for the bus from Mesa to Indianapolis?
The earliest bus departs from Mesa to Indianapolis at 8:40am. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Mesa to Indianapolis?
A bus trip from Mesa to Indianapolis generates an estimated 60 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to Indianapolis was searched and found on Dec 31, 2025 with a price of $238To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to Indianapolis, as early as possible.
You can expect to pay from $238 to $384 for a bus ticket from Mesa to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $238 which is on 2025-12-31.
