Bus Tickets from Knoxville, TN to Manchester, TN, US

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Previously seen trips

One passenger / one way

  • Departure time: November 24 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: November 24 at
    Destination city: Manchester
    Destination location: Manchester
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: March 10 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: March 10 at
    Destination city: Manchester
    Destination location: Manchester
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: June 26 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 26 at
    Destination city: Manchester
    Destination location: Manchester
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: July 24 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: July 24 at
    Destination city: Manchester
    Destination location: Manchester
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: July 26 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: July 26 at
    Destination city: Manchester
    Destination location: Manchester
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Bus Knoxville, TN to Manchester, TN, US: Trip Overview

Average ticket price$64
Average bus trip duration5h 40m
Number of daily buses1
Earliest bus departure6:15pm
Distance129 miles (207 km)

Knoxville to Manchester Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Knoxville to Manchester.

Bus service from Knoxville to Manchester will be provided by the most trusted bus companies.

Discover how much the bus trip from Knoxville to Manchester will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Knoxville, TN - Manchester, TN, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/31
$85
09/01
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Today
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busbud logoThe cheapest trip from Knoxville, TN to Manchester, TN, US was searched and found on Aug 31, 2025 with a price of $85

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Manchester, TN, US, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Knoxville to Manchester but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Knoxville to Manchester, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Knoxville to Manchester will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Manchester.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

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