Bus Tickets from Houston, US to Santa Ana, US

Previously seen trips

Next departures for Houston to Santa Ana on September 20
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Downtown Gray & Smith
Santa Ana Bus StationNo tags
Greyhound + FlixBus
Houston Uptown/Upper Kirby
Santa Ana Bus StationNo tags
Greyhound + FlixBus
Houston Uptown/Upper Kirby
Anaheim Regional Transportation Intermodal CenterNo tags
FlixBus + Greyhound
Houston Uptown/Upper Kirby
UC Irvine (Crawford Hall)No tags
FlixBus + Greyhound
Baytown, 6800 Thompson Rd
UC Irvine (Crawford Hall)No tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Houston, US to Santa Ana, US: Trip Overview

Average ticket price$166
Average bus trip duration1d 16h
Number of daily buses22
Earliest bus departure2:00am
Distance1338 miles (2157 km)
Latest bus departure7:50pm

Houston to Santa Ana Bus

Busbud helps you find a bus from Houston to Santa Ana. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Houston to Santa Ana will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Houston to Santa Ana, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Houston, US - Santa Ana, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/18
No data
09/19
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Today
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09/21
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09/22
$142
09/23
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09/24
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09/25
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busbud logoThe cheapest trip from Houston, US to Santa Ana, US was searched and found on Sep 22, 2025 with a price of $142

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Houston, US to Santa Ana, US, as early as possible.

You can expect to pay from $142 to $155 for a bus ticket from Houston, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $142 which is on 2025-09-22.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Houston and Santa Ana!

Much more than a mere vehicle taking you from Houston to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Houston to Santa Ana that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Houston to Santa Ana, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Houston, US by bus?

Bus from Santa Ana, US to Houston, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

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