Bus Tickets from Framingham to San Diego (CA), US

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TodayMay 23
from $343
TomorrowMay 24
SunMay 25
MonMay 26
TueMay 27
WedMay 28
ThuMay 29
FriMay 30

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 23 at
    Departure city: Framingham
    Departure location: Framingham Intermodal - 2 Franklin St
    Arrival time: May 26 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 23 at
    Departure city: Framingham
    Departure location: Framingham Intermodal - 2 Franklin St
    Arrival time: May 26 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 23 at
    Departure city: Framingham
    Departure location: Framingham Intermodal - 2 Franklin St
    Arrival time: May 26 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 23 at
    Departure city: Framingham
    Departure location: Framingham Intermodal - 2 Franklin St
    Arrival time: May 26 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 23 at
    Departure city: Framingham
    Departure location: Framingham Intermodal - 2 Franklin St
    Arrival time: May 26 at
    Destination city: San Diego
    Destination location: Downtown SD (Seaport)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Bus Framingham to San Diego: Trip Overview

Average ticket price$292
Average bus trip duration3d 6h
Number of daily buses6
Earliest bus departure2:45pm
Distance2554 miles (4119 km)

Framingham to San Diego Bus

With Busbud, comparing and booking tickets for a bus from Framingham to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Framingham to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from Framingham, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Framingham - San Diego (CA), US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/21
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05/22
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Today
$335
05/24
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05/25
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05/26
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05/27
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05/28
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busbud logoThe cheapest trip from Framingham to San Diego was searched and found on May 23, 2025 with a price of $335

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Framingham to San Diego, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Framingham to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Framingham to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Framingham to San Diego.

Tune out to the fine sounds of your best music playlist on your bus trip from Framingham to San Diego while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Framingham by bus?

Bus from Framingham to San Diego

You can also go to San Diego by train

Train from Framingham to San Diego

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