Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | Pensacola Airport | CheapestFastest |
Last refresh of the prices: Yesterday at 10:55 AM CST.
Get from Des Moines to Pensacola
The journey takes about 1 day, 19 hours 5 minutes and with fares starting at just $230, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Pensacola?
Stops in Des Moines
Stops in Pensacola
- A7950 Pensacola Blvd, Pensacola, FL 32534, USA
- B505 W Burgess Rd, Pensacola, FL 32503
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Des Moines to Pensacola by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Pensacola?
The cheapest bus tickets from Des Moines to Pensacola start from $230. The average price for this route is around $230. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Pensacola?
The average bus trip duration from Des Moines to Pensacola is 1d 19h, covering a distance of 848 miles (1367 km). The quickest bus can get you there in 1d 19h and is operated by Greyhound.
Which bus companies service the Des Moines to Pensacola route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Des Moines to Pensacola?
The earliest bus departs from Des Moines to Pensacola at 9:45am. And the latest bus departs at 9:45am.
What are the CO₂ emissions for the bus trip from Des Moines to Pensacola?
A bus trip from Des Moines to Pensacola generates an estimated 34 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Pensacola was searched and found on Jan 17, 2026 with a price of $222To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Pensacola, as early as possible.
You can expect to pay from $222 to $222 for a bus ticket from Des Moines to Pensacola based on the last 2 days. You can expect to find the cheapest price for the trip at $222 which is on 2026-01-17.
Top traveled bus routes
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