Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Fe Depot | AMTRAK Station | CheapestFastest | ||||
| Bus | Santa Fe Depot | Cal Poly Vista Grande Dining Complex | No tags |
Last refresh of the prices: Last Saturday at 1:07 AM PST.
Compare 2 ways to travel from San Diego to San Luis Obispo
Among the sustainable travel choices, the train stands out as a good way to reach San Luis Obispo. The journey takes about 8 hours 47 minutes and with fares starting at just R 1 106, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and San Luis Obispo?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in San Luis Obispo
- A1730 Santa Rosa St, San Luis Obispo, CA 93401, USA
- B
San Luis Obispo Bus Stop
1460 Calle Joaquin, San Luis Obispo, CA 93405, USA
Compare bus companies
Frequently asked questions about travelling from San Diego, CA, US to San Luis Obispo by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from San Diego to San Luis Obispo?
The cheapest bus tickets from San Diego to San Luis Obispo start at R 742. The average price for this route is around R 1 515. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from San Diego to San Luis Obispo?
The average bus journey time from San Diego to San Luis Obispo is 12h 40m, covering a distance of 431 km. The fastest bus gets you there in 7h 50m and is operated by Greyhound.
Which bus companies service the San Diego to San Luis Obispo route?
What is the earliest and latest departure time for the bus from San Diego to San Luis Obispo?
The earliest bus departs from San Diego to San Luis Obispo at 06:45. And the latest bus departs at 22:10.
What are the CO₂ emissions for the bus trip from San Diego to San Luis Obispo?
A bus trip from San Diego to San Luis Obispo produces an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from San Diego to San Luis Obispo?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5627 reviews.
Which bus company has the best Wi-Fi from San Diego to San Luis Obispo?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from San Diego to San Luis Obispo?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to San Luis Obispo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to San Luis Obispo was searched and found on 15 Dec 2025 with a price of R 1 049To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to San Luis Obispo as early as possible.
You can expect to pay from R 1 049 to R 1 891 for a bus ticket from San Diego, CA, US to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 444, which is on 2025-12-18.
