Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 314 Jay St., La Crosse | St. Paul & N5th | Cheapest | ||||
| Bus | La Crosse (U of WI) | St. Paul & N5th | Fastest |
Last refresh of the prices: Last Wednesday at 9:42 PM CST.
Compare 2 ways to travel from La Crosse to Milwaukee
Among the sustainable travel choices, the Train stands out as a good way to reach Milwaukee. The journey takes about 3 hours 36 minutes and with fares starting at just R 424, it presents an excellent value for a comfortable ride.
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Frequently asked questions about travelling from La Crosse, WI to Milwaukee by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from La Crosse to Milwaukee?
The cheapest bus tickets from La Crosse to Milwaukee start at R 654. The average price for this route is around R 654. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from La Crosse to Milwaukee?
The average bus journey time from La Crosse to Milwaukee is 4h 40m, covering a distance of 283 km. The fastest bus gets you there in 3h 45m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Milwaukee route?
Several major bus companies operate on this route with 2 buses available per day, including services from Megabus, Jefferson Lines.
What is the earliest and latest departure time for the bus from La Crosse to Milwaukee?
The earliest bus departs from La Crosse to Milwaukee at 14:10. And the latest bus departs at 16:10.
What are the CO₂ emissions for the bus trip from La Crosse to Milwaukee?
A bus trip from La Crosse to Milwaukee produces an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from La Crosse to Milwaukee?
According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 766 reviews.
Which bus company has the best Wi-Fi from La Crosse to Milwaukee?
Based on reviews on Busbud, the bus company Megabus has the best Wi-Fi rating with a score of 2.4.
Which bus company offers the most punctual service from La Crosse to Milwaukee?
According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines, with a punctuality rating of 3.7 out of 5 stars.
Which bus company has the cleanest buses from La Crosse to Milwaukee?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Jefferson Lines, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Milwaukee was searched and found on 28 Jan 2026 with a price of R 635To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Milwaukee as early as possible.
You can expect to pay from R 635 to R 635 for a bus ticket from La Crosse, WI to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at R 635, which is on 2026-02-04.
