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One passenger / one way
- This trip is recommended because it is the: Cheapest + FastestDeparture time: June 29 atDeparture city: La CrosseDeparture location: La Crosse MTU Transit CenterArrival time: June 29 atDestination city: MilwaukeeDestination location: St. Paul & N5thOperated by: Jefferson Lines
Vehicle: BusDuration: - Departure time: June 29 atDeparture city: La CrosseDeparture location: La Crosse St Andrew StArrival time: June 29 atDestination city: MilwaukeeDestination location: Milwaukee Bus Station, St. Paul & N6th road.Operated by: Megabus US
Vehicle: BusDuration: - Departure time: June 29 atDeparture city: La CrosseDeparture location: La Crosse WI - University of Wisconsin (LSW)Arrival time: June 29 atDestination city: MilwaukeeDestination location: Milwaukee Bus Station, St. Paul & N6th road.Operated by: Megabus USVehicle: BusDuration:
Last refresh of the prices: Yesterday at 9:55 PM CDT.
Prices and availability are subject to change.
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Compare 2 ways to go from La Crosse to Milwaukee
Busbud recommends taking the train from La Crosse to MilwaukeeAmong the sustainable travel choices, the train stands out as a good way to reach Milwaukee. The journey takes about 3 hours 36 minutes, and with fares starting at just US$27, it presents an excellent value for a comfortable ride.
Bus La Crosse to Milwaukee: Trip Overview
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La Crosse to Milwaukee Bus
Busbud helps you find a bus from La Crosse to Milwaukee. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
Bus service from La Crosse to Milwaukee will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Milwaukee from La Crosse, we help you find what you're looking for based on how much of a budget you have.
Frequently asked questions on the trip La Crosse, WI - Milwaukee
What is the distance between La Crosse and Milwaukee?
The distance between La Crosse and Milwaukee is approximately 284 km (176 miles).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse to Milwaukee was searched and found on Jun 26, 2025 with a price of US$39To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse to Milwaukee, as early as possible.
You can expect to pay from US$39 to US$54 for a bus ticket from La Crosse to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at US$39 which is on 2025-06-29.
Usually MEUS - CUWI will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between La Crosse and Milwaukee!
Much more than a mere vehicle taking you from La Crosse to Milwaukee, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Crosse to Milwaukee.
Make a music playlist for your bus ride from La Crosse to Milwaukee, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
What's the cheapest way to go from La Crosse to Milwaukee?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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