Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Greyhound Bus Stop | Mesa Bus Stop | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | Mesa Bus Stop | No tags | ||||
| Bus | Greyhound Bus Stop | Mesa Bus Stop | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | Mesa Bus Stop | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | Mesa Bus Stop | No tags |
Last refresh of the prices: Last Wednesday at 4:37 PM PST.
Get from San Diego to Mesa
The journey takes about 12 hours 35 minutes, and with fares starting at just $122, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Mesa?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Compare bus companies
Frequently asked questions about travelling from San Diego, CA, US to Mesa by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Diego to Mesa?
The cheapest bus tickets from San Diego to Mesa start from $122. The average price for this route is around $153. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to Mesa?
The average bus travel time from San Diego to Mesa is 12h 35m, covering a distance of 505 km. The quickest bus can get you there in 8h 10m and is operated by Greyhound.
Which bus companies service the San Diego to Mesa route?
What are the earliest and latest departure times for the bus from San Diego to Mesa?
The earliest bus departs from San Diego to Mesa at 7:35am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from San Diego to Mesa?
A bus trip from San Diego to Mesa generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from San Diego to Mesa?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from San Diego to Mesa?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from San Diego to Mesa?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Mesa?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Mesa was searched and found on Jan 3, 2026 with a price of $122To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Mesa, as early as possible.
You can expect to pay from $122 to $195 for a bus ticket from San Diego, CA, US to Mesa based on the last 1 days. You can expect to find the cheapest price for the trip at $122 which is on 2026-01-03.
