Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Jacksonville Bus Station | San Diego (Old Town-FlixBus) | Cheapest | ||||
 | Bus | Jacksonville Bus Station | Greyhound Bus Stop | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Jacksonville Bus Station | UCSD Health La Jolla Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Jacksonville Bus Station | UCSD Health La Jolla Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Jacksonville Bus Station | UCSD Health La Jolla Station | No tags |
Last refresh of the prices: Last Wednesday at 11:17 AM EST.
Compare 2 ways to go from Jacksonville to San Diego
Among the sustainable travel choices, the Bus stands out as a good way to reach San Diego. The journey takes about 2 days, 15 hours 45 minutes, and with fares starting at just $271, it presents an excellent value for a comfortable ride.
Where are the popular stops in Jacksonville and San Diego?
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling from Jacksonville, FL to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Jacksonville to San Diego?
The cheapest bus tickets from Jacksonville to San Diego start from $271. The average price for this route is around $516. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Jacksonville to San Diego?
The average bus travel time from Jacksonville to San Diego is 2d 15h, covering a distance of 3360 km. The quickest bus can get you there in 2d 11h and is operated by Greyhound.
Which bus companies service the Jacksonville to San Diego route?
What are the earliest and latest departure times for the bus from Jacksonville to San Diego?
The earliest bus departs from Jacksonville to San Diego at 9:05am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Jacksonville to San Diego?
A bus trip from Jacksonville to San Diego generates an estimated 84 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Jacksonville to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which bus company has the best Wi-Fi from Jacksonville to San Diego?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Jacksonville to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Jacksonville to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to San Diego, CA, US was searched and found on Jan 20, 2026 with a price of $267To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to San Diego, CA, US, as early as possible.
You can expect to pay from $267 to $966 for a bus ticket from Jacksonville, FL to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $267 which is on 2026-01-20.
What's the cheapest way to go from Jacksonville, FL to San Diego, CA, US?
The Bus is the cheapest travel choice for this destination
