Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Big Pine Key, FL | 151 Steel Pl, Cambridge | Cheapest | ||||
 | Bus | Big Pine Key, FL | Boston (South Station) | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Big Pine Key, FL | Boston (South Station) | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Big Pine Key, FL | Brookline | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Big Pine Key, FL | Brookline | No tags |
Last refresh of the prices: Last Wednesday at 10:39 PM EST.
Get from Big Pine Key to Boston
The journey takes about 2 days, 1 hour 40 minutes, and with fares starting at just $321, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87498 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $321
Frequently asked questions about travelling from Big Pine Key to Boston, MA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Big Pine Key to Boston?
The cheapest bus tickets from Big Pine Key to Boston start from $321. The average price for this route is around $331. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Big Pine Key to Boston?
The average bus travel time from Big Pine Key to Boston is 2d 1h, covering a distance of 2179 km. The quickest bus can get you there in 1d 18h and is operated by Greyhound.
Which bus companies service the Big Pine Key to Boston route?
Several major bus companies operate on this route with 6 buses available per day.
What are the earliest and latest departure times for the bus from Big Pine Key to Boston?
The earliest bus departs from Big Pine Key to Boston at 10:40am. And the latest bus departs at 5:40pm.
What are the CO₂ emissions for the bus trip from Big Pine Key to Boston?
A bus trip from Big Pine Key to Boston generates an estimated 54 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Big Pine Key to Boston, MA, US was searched and found on Jan 13, 2026 with a price of $311To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Big Pine Key to Boston, MA, US, as early as possible.
You can expect to pay from $311 to $321 for a bus ticket from Big Pine Key to Boston, MA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $314 which is on 2026-01-14.
