Next bus departures Today, Mar 19 Tomorrow, Mar 20 Sat, Mar 21 Sun, Mar 22 Mon, Mar 23 Tue, Mar 24 Wed, Mar 25 Thu, Mar 26 More dates
Next departures for Pittsburgh to Chicago on March 19 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station Cheapest $97 Bus 7:45pm
Pittsburgh Intermodal Station 10h 55m 5:40am
Chicago 95Th & Dan Ryan Fastest $108 Bus 8:35am
Pittsburgh Intermodal Station 12h 30m 8:05pm
Downtown Greyhound Station No tags $106 Greyhound Lines, Inc. + FlixBus
Bus 8:00pm
Pittsburgh Intermodal Station 14h 50m 9:50am
Chicago 95Th & Dan Ryan No tags $173 Bus 8:50am
Pittsburgh Intermodal Station 12h 15m 8:05pm
Downtown Greyhound Station No tags $118
Next departures for Pittsburgh to Chicago on March 20 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 12:55am
Pittsburgh Intermodal Station 10h 5m 10:00am
Downtown Greyhound Station Cheapest Fastest $92 Bus 1:20am
Pittsburgh Intermodal Station 14h 15m 2:35pm
Downtown Greyhound Station No tags $152 Greyhound Lines, Inc. + FlixBus
Bus 1:25am
Pittsburgh Intermodal Station 17h 10m 5:35pm
Downtown Greyhound Station No tags $126 Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station No tags $92 Bus 8:35am
Pittsburgh Intermodal Station 12h 30m 8:05pm
Downtown Greyhound Station No tags $97
Next departures for Pittsburgh to Chicago on March 21 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station Cheapest $78 Bus 12:55am
Pittsburgh Intermodal Station 10h 5m 10:00am
Downtown Greyhound Station Fastest $82 Bus 1:20am
Pittsburgh Intermodal Station 14h 15m 2:35pm
Downtown Greyhound Station No tags $100 Greyhound Lines, Inc. + FlixBus
Bus 1:25am
Pittsburgh Intermodal Station 17h 10m 5:35pm
Downtown Greyhound Station No tags $100 Bus 7:45pm
Pittsburgh Intermodal Station 10h 55m 5:40am
Chicago 95Th & Dan Ryan No tags $82
Next departures for Pittsburgh to Chicago on March 22 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 12:55am
Pittsburgh Intermodal Station 10h 5m 10:00am
Downtown Greyhound Station Cheapest Fastest $76 Bus 1:20am
Pittsburgh Intermodal Station 14h 15m 2:35pm
Downtown Greyhound Station No tags $122 Greyhound Lines, Inc. + FlixBus
Bus 1:25am
Pittsburgh Intermodal Station 17h 10m 5:35pm
Downtown Greyhound Station No tags $100 Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station No tags $82 Bus 8:35am
Pittsburgh Intermodal Station 12h 30m 8:05pm
Downtown Greyhound Station No tags $78
Next departures for Pittsburgh to Chicago on March 23 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 12:55am
Pittsburgh Intermodal Station 10h 5m 10:00am
Downtown Greyhound Station Cheapest Fastest $70 Bus 1:20am
Pittsburgh Intermodal Station 14h 15m 2:35pm
Downtown Greyhound Station No tags $96 Greyhound Lines, Inc. + FlixBus
Bus 1:25am
Pittsburgh Intermodal Station 17h 10m 5:35pm
Downtown Greyhound Station No tags $81 Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station No tags $74 Bus 8:35am
Pittsburgh Intermodal Station 12h 30m 8:05pm
Downtown Greyhound Station No tags $72
Next departures for Pittsburgh to Chicago on March 24 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 12:55am
Pittsburgh Intermodal Station 10h 5m 10:00am
Downtown Greyhound Station Cheapest Fastest $66 Bus 1:20am
Pittsburgh Intermodal Station 14h 15m 2:35pm
Downtown Greyhound Station No tags $89 Greyhound Lines, Inc. + FlixBus
Bus 1:25am
Pittsburgh Intermodal Station 17h 10m 5:35pm
Downtown Greyhound Station No tags $90 Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station No tags $70 Bus 8:35am
Pittsburgh Intermodal Station 12h 30m 8:05pm
Downtown Greyhound Station No tags $74
Next departures for Pittsburgh to Chicago on March 25 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 8:35am
Pittsburgh Intermodal Station 12h 30m 8:05pm
Downtown Greyhound Station Cheapest $63 Bus 12:55am
Pittsburgh Intermodal Station 10h 5m 10:00am
Downtown Greyhound Station Fastest $66 Bus 1:20am
Pittsburgh Intermodal Station 14h 15m 2:35pm
Downtown Greyhound Station No tags $97 Greyhound Lines, Inc. + FlixBus
Bus 1:25am
Pittsburgh Intermodal Station 17h 10m 5:35pm
Downtown Greyhound Station No tags $90 Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station No tags $85
Next departures for Pittsburgh to Chicago on March 26 Operated by Vehicle type Departure time Departure location Trip duration Arrival time Arrival location Recommended Price and booking link Bus 8:35am
Pittsburgh Intermodal Station 12h 30m 8:05pm
Downtown Greyhound Station Cheapest $65 Bus 12:55am
Pittsburgh Intermodal Station 10h 5m 10:00am
Downtown Greyhound Station Fastest $68 Bus 1:20am
Pittsburgh Intermodal Station 14h 15m 2:35pm
Downtown Greyhound Station No tags $83 Greyhound Lines, Inc. + FlixBus
Bus 1:25am
Pittsburgh Intermodal Station 17h 10m 5:35pm
Downtown Greyhound Station No tags $82 Bus 7:45pm
Pittsburgh Intermodal Station 11h 25m 6:10am
Downtown Greyhound Station No tags $72
Last refresh of the prices: Today at 3:05 AM EDT.
View all departures Where are the popular stops in Pittsburgh and Chicago? Stops in Pittsburgh B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA Map
Stops in Chicago C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA Map
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA Map
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA Map
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA Map
Find cheapest prices for buses Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Chicago was searched and found on Mar 24, 2026 with a price of $58 To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Chicago, as early as possible.
You can expect to pay from $58 to $210 for a bus ticket from Pittsburgh to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $58 which is on 2026-03-24.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
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Popular bus departures from Pittsburgh Popular bus routes to Chicago Continue your journey from Chicago 
The cheapest trip from Pittsburgh to Chicago was searched and found on Mar 24, 2026 with a price of $58
