Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Südseite Hauptbahnhof | PRG Airport | CheapestFastest | |||||
| Südseite Hauptbahnhof | Prague (Central Bus Station Florenc) | No tags | |||||
Flixtrain + Flixbus | Karlsruhe Hbf | Prague (Main Station - parking) | No tags | |||||
| Südseite Hauptbahnhof | Prague (Central Bus Station Florenc) | No tags | |||||
| Südseite Hauptbahnhof | Prague (Central Bus Station Florenc) | No tags |
Last refresh of the prices: Today at 11:34 AM CET.
Compare 3 ways to go from Karlsruhe to Prague
Among the sustainable travel choices, the carpool stands out as the good way to reach Prague. The journey takes about 5 hours 20 minutes and with fares starting at just $29, it presents an excellent value for a comfortable ride.
Where are the popular stops in Karlsruhe and Prague?
Stops in Karlsruhe
- AHinterm Hauptbahnhof 6, 76137 Karlsruhe, Germany
- BBahnhofpl. 1A, 76137 Karlsruhe, Germany
- CGoethestraße 17-19, 76135 Karlsruhe, Germany
- D
Karlsruhe
Gartenstraße 58, 76135 Karlsruhe, Germany - E
Karlsruhe/Baden-Baden Airport
Quebec Avenue, 77836 Rheinmünster, Germany
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- B
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - CAviatická, 161 08, Praha 6, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F300/8 Wilsonova, 110 00 Praha, Czechia
Compare bus companies
Frequently asked questions about traveling from Karlsruhe to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Karlsruhe to Prague?
The cheapest bus tickets from Karlsruhe to Prague start from $32. The average price for this route is around $54. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Karlsruhe to Prague?
The average bus trip duration from Karlsruhe to Prague is 10h 25m, covering a distance of 281 miles (452 km). The quickest bus can get you there in 7h 45m and is operated by FlixBus.
Which bus companies service the Karlsruhe to Prague route?
Several major bus companies operate on this route with 17 buses available per day, including services from FlixBus, BlaBlaCar Bus, KLR Bus, LEX CLUB.
What is the earliest and latest departure time for the bus from Karlsruhe to Prague?
The earliest bus departs from Karlsruhe to Prague at 12:05am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Karlsruhe to Prague?
A bus trip from Karlsruhe to Prague generates an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Karlsruhe to Prague?
According to Busbud customers, the highest-rated bus company on this route is KLR Bus, with an average rating of 4.2 out of 5 stars based on 19 reviews.
Which bus company has the best Wi-Fi from Karlsruhe to Prague?
Based on reviews on Busbud, the bus company KLR Bus has the best Wi-Fi rating with a score of 4.5.
Which bus company has the most timely service from Karlsruhe to Prague?
According to Busbud traveller reviews, the most timely bus company on this route is KLR Bus, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Karlsruhe to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is KLR Bus, with a cleanliness rating of 5.0 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Karlsruhe to Prague was searched and found on Dec 15, 2025 with a price of $28To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Prague, as early as possible.
You can expect to pay from $28 to $126 for a bus ticket from Karlsruhe to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $41 which is on 2025-12-16.
