How much is the bus ticket from Rome to Isernia?

The cheapest bus tickets from Rome to Isernia start at R 197. The average price for this route is around R 340. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

How long is the bus journey from Rome to Isernia?

The average bus journey time from Rome to Isernia is 6h 44m, covering a distance of 139 km. The fastest bus gets you there in 2h 10m and is operated by FlixBus .

Which bus companies service the Rome to Isernia route?

Several major bus companies operate on this route with 2 buses available per day.

What is the earliest and latest departure time for the bus from Rome to Isernia?

The earliest bus departs from Rome to Isernia at 04:05. And the latest bus departs at 14:50.

What are the CO₂ emissions for the bus trip from Rome to Isernia?

A bus trip from Rome to Isernia produces an estimated 3 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

Bus Rome to Isernia from R 169 | Refundable Tickets

Next bus departures

Next departures from Rome to Isernia on 30 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	CheapestFastest

Next departures from Rome to Isernia on 31 January
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	CheapestFastest
Bus	04:05	Rome Fiumicino Airport	7h 19m	11:24	Isernia	No tags
Bus	04:40	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24	Isernia	No tags

Next departures from Rome to Isernia on 1 February
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	CheapestFastest
Bus	04:05	Rome Fiumicino Airport	7h 19m	11:24	Isernia	No tags
Bus	04:40	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24	Isernia	No tags

Next departures from Rome to Isernia on 2 February
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	CheapestFastest
Bus	04:05	Rome Fiumicino Airport	7h 19m	11:24	Isernia	No tags
Bus	04:40	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24	Isernia	No tags

Next departures from Rome to Isernia on 3 February
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	04:40	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24	Isernia	Cheapest
Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	Fastest
Bus	04:05	Rome Fiumicino Airport	7h 19m	11:24	Isernia	No tags

Next departures from Rome to Isernia on 4 February
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	04:40	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24	Isernia	Cheapest
Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	Fastest
Bus	04:05	Rome Fiumicino Airport	7h 19m	11:24	Isernia	No tags

Next departures from Rome to Isernia on 5 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	CheapestFastest

Next departures from Rome to Isernia on 6 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	14:50	Rome Tiburtina Bus Station	2h 10m	17:00	Isernia	CheapestFastest

Last refresh of the prices: Today at 1:16 AM CET.

Compare 3 ways to travel from Rome to Isernia

We recommend carpooling

Among the sustainable travel choices, the Carpool stands out as a good way to reach Isernia. The journey takes about 1 hour 50 minutes and with fares starting at just R 124, it presents an excellent value for a comfortable ride.

4carpool per day

1h 50mAverage duration

149 kmDistance

6kgCO₂ emissions

	Average price	Average duration	CO₂ emissions
Bus	Average priceR 197 - R 1 017	Average duration6h 44m	CO₂ emissions 3kg CO₂e
Train	Average priceR 297 - R 479	Average duration2h 15m	CO₂ emissions 4kg CO₂e
Carpool	Average priceR 124 - R 363	Average duration1h 50m	CO₂ emissions 6kg CO₂e

Where are the popular stops in Rome and Isernia?

Stops in Rome

A
Rome Ciampino Airport
Visit page
B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy
Visit page
C
Rome Fiumicino Airport (FCO)
Visit page
D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy
E
Roma
F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy

Stops in Isernia

A
Isernia
Piazza della Repubblica, 9, 86170 Isernia IS, Italy
Visit page

Compare bus companies

FlixBus

3.5/512 163 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

Based on 12163 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. FlixBus ticket prices on this trip start at R 197

IT bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Rede Expressos, Trenitalia

Frequently asked questions about travelling from Rome to Isernia by bus

Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

How much is the bus ticket from Rome to Isernia?
The cheapest bus tickets from Rome to Isernia start at R 197. The average price for this route is around R 340. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Rome to Isernia?
The average bus journey time from Rome to Isernia is 6h 44m, covering a distance of 139 km. The fastest bus gets you there in 2h 10m and is operated by FlixBus.
Which bus companies service the Rome to Isernia route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Rome to Isernia?
The earliest bus departs from Rome to Isernia at 04:05. And the latest bus departs at 14:50.
What are the CO₂ emissions for the bus trip from Rome to Isernia?
A bus trip from Rome to Isernia produces an estimated 3 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

28/01

R 201

29/01

R 200

Today

R 200

31/01

R 189

01/02

R 349

02/02

R 169

03/02

R 349

04/02

R 339

The cheapest trip from Rome to Isernia was searched and found on 02 Feb 2026 with a price of R 169

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Isernia as early as possible.

You can expect to pay from R 169 to R 687 for a bus ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at R 169, which is on 2026-02-02.