Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags |
Get from Knoxville to St. Louis
The journey takes about 21 hours 50 minutes, and with fares starting at just R 1 790, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and St. Louis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87518 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. Greyhound ticket prices on this trip start at R 1 972
Frequently asked questions about travelling from Knoxville, TN to St. Louis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Knoxville to St. Louis?
The cheapest bus tickets from Knoxville to St. Louis start at R 1 790. The average price for this route is around R 2 179. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Knoxville to St. Louis?
The average bus journey time from Knoxville to St. Louis is 21h 50m, covering a distance of 631 km. The fastest bus gets you there in 21h 15m and is operated by Greyhound.
Which bus companies service the Knoxville to St. Louis route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Knoxville to St. Louis?
The earliest bus departs from Knoxville to St. Louis at 18:10. And the latest bus departs at 19:40.
What are the CO₂ emissions for the bus trip from Knoxville to St. Louis?
A bus trip from Knoxville to St. Louis produces an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to St. Louis was searched and found on 04 Feb 2026 with a price of R 2 101To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to St. Louis as early as possible.
You can expect to pay from R 2 101 to R 2 101 for a bus ticket from Knoxville, TN to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 101, which is on 2026-02-04.
