Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | Cheapest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Gray & Smith | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | No tags |
Last refresh of the prices: Last Tuesday at 3:17 AM CST.
Get from Tupelo to Houston
The journey takes about 23 hours 35 minutes, and with fares starting at just $183, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87456 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $184
Greyhound Tupelo Houston recent customer reviews
Bus was late bc of the snow storm..But there was no heat and the bus broke down 4x on way to memphis.. The bus driver held all passengers pretty much hostage . Even the lady with her baby that was freezing . We were stuck in a traffic jam not moving for almost an hour.The bus driver should took the inhumane conditions seriously since everyone was freezing with no heat
Alvin J.
Frequently asked questions about travelling from Tupelo to Houston, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Houston?
The cheapest bus tickets from Tupelo to Houston start from $183. The average price for this route is around $279. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Houston?
The average bus travel time from Tupelo to Houston is 23h 35m, covering a distance of 800 km. The quickest bus can get you there in 17h 40m and is operated by Greyhound.
Which bus companies service the Tupelo to Houston route?
Several major bus companies operate on this route with 10 buses available per day.
What are the earliest and latest departure times for the bus from Tupelo to Houston?
The earliest bus departs from Tupelo to Houston at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Houston?
A bus trip from Tupelo to Houston generates an estimated 20 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Houston, US was searched and found on Dec 26, 2025 with a price of $174To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Houston, US, as early as possible.
You can expect to pay from $174 to $315 for a bus ticket from Tupelo to Houston, US based on the last 2 days. You can expect to find the cheapest price for the trip at $190 which is on 2025-12-31.
