Bus Tickets from St. Louis to Tupelo

Next departures

Next departures for St. Louis to Tupelo on September 21
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Gateway Station
Tupelo (Brothers Quick Stop)Cheapest
FlixBus + Greyhound Lines, Inc.
Gateway Station
Tupelo (Brothers Quick Stop)Fastest

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus St. Louis to Tupelo: Trip Overview

Average Ticket PriceUS$63
Average Bus Trip Duration7h 5m
Number of daily buses2
Earliest bus departure1:00am
Distance506 km
Latest bus departure4:00pm

St. Louis to Tupelo Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to Tupelo.

We make sure you can find a bus service from St. Louis to Tupelo from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Tupelo from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - Tupelo

  1. What is the travel distance from St. Louis to Tupelo?

    St. Louis and Tupelo are 508 km (315 miles) apart.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-18
No data
09-19
US$54
Today
US$69
09-21
US$53
09-22
US$57
09-23
No data
09-24
No data
09-25
No data
busbud logoThe cheapest trip from St. Louis to Tupelo was searched and found on Sep 21, 2025 with a price of US$53

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Tupelo, as early as possible.

You can expect to pay from US$53 to US$69 for a bus ticket from St. Louis to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at US$53 which is on 2025-09-21.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to Tupelo but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Tupelo, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Tupelo.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Tupelo while indulging in miles on end of beautiful scenic views.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to St. Louis by bus?

Bus from Tupelo to St. Louis

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