Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Aeroporto Ciampino Airport (CIA) | Terminal Interbus | No tags | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | Terminal Interbus | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Terminal Interbus | No tags | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | Terminal Interbus | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Terminal Interbus | No tags |
Compare 2 ways to go from Rome to Syracuse
Among the sustainable travel choices, the Train stands out as a good way to reach Syracuse. The journey takes about 11 hours 5 minutes, and with fares starting at just $81, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Syracuse?
Stops in Rome
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Compare bus companies
Based on 12351 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at $50
Frequently asked questions about travelling from Rome to Syracuse by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Rome to Syracuse?
The cheapest bus tickets from Rome to Syracuse start from $50. The average price for this route is around $94. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Rome to Syracuse?
The average bus travel time from Rome to Syracuse is 22h, covering a distance of 588 km. The quickest bus can get you there in 12h and is operated by FlixBus.
Which bus companies service the Rome to Syracuse route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Rome to Syracuse?
The earliest bus departs from Rome to Syracuse at 12:45am. And the latest bus departs at 11:55pm.
What are the CO₂ emissions for the bus trip from Rome to Syracuse?
A bus trip from Rome to Syracuse generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Syracuse was searched and found on Mar 24, 2026 with a price of $53To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Syracuse, as early as possible.
You can expect to pay from $53 to $170 for a bus ticket from Rome to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at $53 which is on 2026-03-24.
What's the cheapest way to go from Rome to Syracuse?
The Bus is the cheapest travel choice for this destination
