Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Parcheggio Via Pietransantina | Terminal Bus Palermo | CheapestFastest | ||||
| Bus | Parcheggio Via Pietransantina | Terminal Bus Palermo | No tags |
Last refresh of the prices: Yesterday at 11:28 PM CEST.
Get from Pisa to Palermo
The journey takes about 21 hours 55 minutes, and with fares starting at just $91, it presents an excellent value for a comfortable ride.
Where are the popular stops in Pisa and Palermo?
Stops in Pisa
- BVia Pietrasantina, 56123 Pisa PI
- C
Piazza della Stazione
Piazza della Stazione, 1, 56125 Pisa PI, Italy
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- EVia Paolo Balsamo, 21, 90123 Palermo, Italy
- F
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy
Compare bus companies
Based on 12381 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at $91
Frequently asked questions about travelling from Pisa to Palermo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Pisa to Palermo?
The cheapest bus tickets from Pisa to Palermo start from $91. The average price for this route is around $112. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pisa to Palermo?
The average bus travel time from Pisa to Palermo is 21h 55m, covering a distance of 674 km. The quickest bus can get you there in 20h 35m and is operated by FlixBus.
Which bus companies service the Pisa to Palermo route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Pisa to Palermo?
The earliest bus departs from Pisa to Palermo at 6:05am. And the latest bus departs at 5:25pm.
What are the CO₂ emissions for the bus trip from Pisa to Palermo?
A bus trip from Pisa to Palermo generates an estimated 16.826974999999997 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pisa to Palermo was searched and found on Apr 2, 2026 with a price of $147To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pisa to Palermo, as early as possible.
You can expect to pay from $147 to $270 for a bus ticket from Pisa to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at $147 which is on 2026-04-02.
What's the cheapest way to go from Pisa to Palermo?
The Bus is the cheapest travel choice for this destination
