Bus Tickets from Panama City, US to Gainesville, FL

Next departures

Next departures for Panama City to Gainesville on September 21
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Panama City Beach Station
Gainesville Bus StopCheapest
Greyhound Lines, Inc.
Panama City Beach Station
Gainesville Bus StopFastest

Accepted payments

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Bus Panama City, US to Gainesville, FL: Trip Overview

Average Ticket PriceUS$46
Average Bus Trip Duration5h 40m
Number of daily buses2
Earliest bus departure7:40am
Distance333 km
Latest bus departure12:50pm

Panama City to Gainesville Bus

Busbud helps you find a bus from Panama City to Gainesville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Panama City to Gainesville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Gainesville from Panama City, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Panama City, US - Gainesville, FL

  1. What is the travel distance from Panama City to Gainesville?

    Panama City and Gainesville are 328 km (204 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Panama City to Gainesville?

    Buses departing from Panama City Greyhound Bus Station in Panama City will take you to Rosa Parks Station in Gainesville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-15
No data
09-16
US$26
Today
No data
09-18
No data
09-19
No data
09-20
No data
09-21
US$32
09-22
No data
busbud logoThe cheapest trip from Panama City, US to Gainesville, FL was searched and found on Sep 16, 2025 with a price of US$26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Gainesville, FL, as early as possible.

You can expect to pay from US$26 to US$37 for a bus ticket from Panama City, US to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at US$32 which is on 2025-09-21.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Gainesville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Gainesville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Panama City to Gainesville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Gainesville.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Panama City, US by bus?

Bus from Gainesville, FL to Panama City, US

Why choose Busbud?

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