Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Louisville, KY | Greyhound Bus Stop | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Louisville, KY | UCSD Health La Jolla Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Louisville, KY | San Diego (Old Town-FlixBus) | No tags | ||||
| Bus | Louisville, KY | Greyhound Bus Stop | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Louisville, KY | San Diego (Old Town-FlixBus) | No tags |
Last refresh of the prices: Yesterday at 10:55 PM EST.
Get from Louisville to San Diego
The journey takes about 2 days, 9 hours 10 minutes, and with fares starting at just $490, it presents an excellent value for a comfortable ride.
Where are the popular stops in Louisville and San Diego?
Stops in Louisville
- A
Louisville Greyhound Bus Station
720 W Muhammad Ali Blvd, Louisville, KY 40203
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling from Louisville to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Louisville to San Diego?
The cheapest bus tickets from Louisville to San Diego start from $490. The average price for this route is around $663. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Louisville to San Diego?
The average bus travel time from Louisville to San Diego is 2d 9h, covering a distance of 2895 km. The quickest bus can get you there in 2d 2h and is operated by Greyhound.
Which bus companies service the Louisville to San Diego route?
What are the earliest and latest departure times for the bus from Louisville to San Diego?
The earliest bus departs from Louisville to San Diego at 3:35am. And the latest bus departs at 10:55pm.
What are the CO₂ emissions for the bus trip from Louisville to San Diego?
A bus trip from Louisville to San Diego generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Louisville to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87412 reviews.
Which bus company has the best Wi-Fi from Louisville to San Diego?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Louisville to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Louisville to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Louisville to San Diego, CA, US was searched and found on Dec 12, 2025 with a price of $548To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Louisville to San Diego, CA, US, as early as possible.
You can expect to pay from $548 to $674 for a bus ticket from Louisville to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $602 which is on 2025-12-19.
