Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Indianapolis Bus Station | Winston Salem Greyhound Bus Station | Cheapest | ||||
 | Bus | Indianapolis Bus Station | Winston Salem Greyhound Bus Station | Fastest | ||||
| Bus | Indianapolis Bus Station | Winston Salem Greyhound Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | Winston Salem Greyhound Bus Station | No tags |
Last refresh of the prices: Last Friday at 2:47 AM EST.
Get from Indianapolis to Winston-Salem
The journey takes about 19 hours 35 minutes, and with fares starting at just $140, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Winston-Salem?
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
Stops in Winston-Salem
- A
Winston Salem Greyhound Bus Station
100 W 5th St, Winston Salem, NC 27101 - B
E Sprague St
841 E Sprague St, Winston-Salem, NC 27107, USA - C
Winston-Salem Bus Stop
2500 Old Lexington Rd, Winston-Salem, NC 27107, USA - D
1237 Silas Creek Pkwy
1237 Silas Creek Pkwy., Winston-Salem, NC 27127 (Hong Kong King Buffet)
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Frequently asked questions about travelling from Indianapolis to Winston-Salem by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Indianapolis to Winston-Salem?
The cheapest bus tickets from Indianapolis to Winston-Salem start from $140. The average price for this route is around $245. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to Winston-Salem?
The average bus travel time from Indianapolis to Winston-Salem is 19h 35m, covering a distance of 660 km. The quickest bus can get you there in 14h 20m and is operated by Greyhound.
Which bus companies service the Indianapolis to Winston-Salem route?
What are the earliest and latest departure times for the bus from Indianapolis to Winston-Salem?
The earliest bus departs from Indianapolis to Winston-Salem at 4:30am. And the latest bus departs at 7:55pm.
What are the CO₂ emissions for the bus trip from Indianapolis to Winston-Salem?
A bus trip from Indianapolis to Winston-Salem generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Indianapolis to Winston-Salem?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Indianapolis to Winston-Salem?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Indianapolis to Winston-Salem?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to Winston-Salem?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Winston-Salem was searched and found on Jan 13, 2026 with a price of $140To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Winston-Salem, as early as possible.
You can expect to pay from $140 to $214 for a bus ticket from Indianapolis to Winston-Salem based on the last 2 days. You can expect to find the cheapest price for the trip at $140 which is on 2026-01-13.
