Bus Tickets from Indianapolis to Buffalo, NY

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TodaySep 3
from US$101
TomorrowSep 4
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WedSep 10

Next departures to Buffalo

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: September 4 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: September 4 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Greyhound Amtrak Station
    Arrival time: September 4 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: September 4 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 3 at
    Departure city: Indianapolis
    Departure location: Greyhound Amtrak Station
    Arrival time: September 4 at
    Destination city: Buffalo
    Destination location: Depew Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

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Compare 2 ways to go from Indianapolis to Buffalo

Bus
Average PriceUS$81 - US$178Average Duration17h 45m
18kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$207 - US$235Average Duration1d 2h
65kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Indianapolis to Buffalo

Among the sustainable travel choices, the bus stands out as a good way to reach Buffalo. The journey takes about 17 hours 45 minutes, and with fares starting at just US$81, it presents an excellent value for a comfortable ride.

4bus per day
17h 45mAverage Duration
US$81Cheapest ticket
18kgCO₂ emissions

Bus Indianapolis to Buffalo, NY: Trip Overview

Average Ticket PriceUS$114
Average Bus Trip Duration17h 45m
Number of daily buses4
Earliest bus departure12:25am
Distance700 km
Latest bus departure11:30pm

Indianapolis to Buffalo Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to Buffalo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Indianapolis to Buffalo.

Discover how much the bus trip from Indianapolis to Buffalo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Indianapolis - Buffalo, NY

  1. What is the travel distance from Indianapolis to Buffalo?

    The distance covered from Indianapolis to Buffalo is 701 km (435 miles).

  2. What are the departure and arrival locations for buses traveling from Indianapolis to Buffalo?

    Buses traveling this route start their trip at Greyhound Amtrak Station, in Indianapolis, and end it at Buffalo Airport, in Buffalo.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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US$94
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busbud logoThe cheapest trip from Indianapolis to Buffalo, NY was searched and found on Sep 3, 2025 with a price of US$94

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Buffalo, NY, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Indianapolis to Buffalo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Indianapolis to Buffalo.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Indianapolis to Buffalo will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to Buffalo while indulging in miles on end of beautiful scenic views.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from Indianapolis to Buffalo, NY?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from Buffalo, NY to Indianapolis

You can also go to Buffalo, NY by train

Train from Indianapolis to Buffalo, NY

Why choose Busbud?

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