Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Harrisburg Bus Station | Gateway Station | No tags | ||||
| Bus | Harrisburg Bus Station | Gateway Station | No tags | ||||
| Bus | Harrisburg Bus Station | Gateway Station | No tags | ||||
| Bus | Harrisburg Bus Station | Gateway Station | No tags | ||||
| Bus | Harrisburg Bus Station | Gateway Station | No tags |
Compare 2 ways to go from Harrisburg to St. Louis
Among the sustainable travel choices, the Bus stands out as a good way to reach St. Louis. The journey takes about 20 hours 35 minutes, and with fares starting at just $166, it presents an excellent value for a comfortable ride.
Where are the popular stops in Harrisburg and St. Louis?
Compare bus companies
Frequently asked questions about travelling from Harrisburg to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Harrisburg to St. Louis?
The cheapest bus tickets from Harrisburg to St. Louis start from $166. The average price for this route is around $245. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Harrisburg to St. Louis?
The average bus travel time from Harrisburg to St. Louis is 20h 35m, covering a distance of 1158 km. The quickest bus can get you there in 17h 20m and is operated by Greyhound.
Which bus companies service the Harrisburg to St. Louis route?
What are the earliest and latest departure times for the bus from Harrisburg to St. Louis?
The earliest bus departs from Harrisburg to St. Louis at 2:30am. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Harrisburg to St. Louis?
A bus trip from Harrisburg to St. Louis generates an estimated 29 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Harrisburg to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Harrisburg to St. Louis?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Harrisburg to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Harrisburg to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to St. Louis was searched and found on Jan 8, 2026 with a price of $160To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to St. Louis, as early as possible.
What's the cheapest way to go from Harrisburg to St. Louis?
The Bus is the cheapest travel choice for this destination
