Bus Tickets from Greenville (SC) to Durham (NC), US

Find affordable bus tickets from Greenville (SC) to Durham (NC), US with flexible options. Book your trip now

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TodayJun 12
from US$42
TomorrowJun 13
from US$42
SatJun 14
SunJun 15
from US$43
MonJun 16
TueJun 17
from US$42
WedJun 18
from US$44
ThuJun 19
from US$44

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 13 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: June 14 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 13 at
    Departure city: Greenville
    Departure location: Greenville, (SC - Taqueria Guadalajara #3)
    Arrival time: June 13 at
    Destination city: Durham
    Destination location: Durham
    Operated by: Tornado BusTornado Bus
    Vehicle: BusDuration:
  • Departure time: June 13 at
    Departure city: Greenville
    Departure location: 1111 Woodruff Road
    Arrival time: June 13 at
    Destination city: Durham
    Destination location: BP Gas Station
    Operated by: Wanda CoachWanda Coach
    Vehicle: BusDuration:
  • Departure time: June 13 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: June 13 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 13 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: June 13 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Last Friday at 9:54 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
  • Diners Club Canada
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  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Greenville to Durham

Bus
Average PriceUS$41 - US$158Average Duration4h 45m
8kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$67 - US$106Average Duration7h
31kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Greenville to Durham

Among the sustainable travel choices, the bus stands out as a good way to reach Durham. The journey takes about 4 hours 45 minutes, and with fares starting at just US$41, it presents an excellent value for a comfortable ride.

9.5bus per day
4h 45mAverage Duration
US$41Cheapest ticket
8kgCO₂ emissions

Bus Greenville to Durham: Trip Overview

Average Ticket PriceUS$56
Average Bus Trip Duration4h 45m
Number of daily buses9
Earliest bus departure7:40am
Distance334 km
Latest bus departure10:00pm

Greenville to Durham Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Durham.

We make sure you can find a bus service from Greenville to Durham from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Durham from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Greenville (SC) - Durham (NC), US

  1. How long is the bus ride from Greenville to Durham?

    The bus ride from Greenville to Durham takes 4h 45m, on average. For the shortest travel time, select the fastest bus available, which will take you to Durham in about 4h 28m.

  2. How far is Greenville from Durham?

    It's about 342 km (212 miles) from Greenville to Durham.

  3. What are the departure and arrival locations for buses traveling from Greenville to Durham?

    Buses departing from Guadalajara Supermarket Bus Stop in Greenville will take you to Durham Greyhound Bus Station in Durham.

  4. What is the cheapest way to travel from Greenville to Durham?

    Taking the bus is the most budget-friendly option to travel from Greenville to Durham. Starting at US$41, this bus is the most cost-effective option for your journey.

  5. How much does it cost to take the bus from Greenville to Durham?

    You can expect to pay around US$56 for the bus ride from Greenville to Durham.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-10
US$32
06-11
US$32
Today
US$34
06-13
US$34
06-14
US$34
06-15
US$35
06-16
US$34
06-17
US$34
busbud logoThe cheapest trip from Greenville to Durham was searched and found on Jun 10, 2025 with a price of US$32

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville to Durham, as early as possible.

You can expect to pay from US$32 to US$150 for a bus ticket from Greenville to Durham based on the last 2 days. You can expect to find the cheapest price for the trip at US$34 which is on 2025-06-13.

Usually Expreso will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Durham but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Greenville to Durham, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Durham.

Make a music playlist for your bus ride from Greenville to Durham, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Greenville to Durham?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville by bus?

Bus from Greenville to Durham

You can also go to Durham by train

Train from Greenville to Durham

Why choose Busbud?

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