Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Cherry Hill Mall | Cheapest | ||||
 | Bus | Des Moines | 199 Spring Garden St. | Fastest | ||||
| Bus | Des Moines | 199 Spring Garden St. | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Philadelphia, 199 Spring Garden St | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Frazer - 56-40 Matthews Rd | No tags |
Last refresh of the prices: Last Tuesday at 12:41 PM CST.
Get from Des Moines to Philadelphia
The journey takes about 1 day, 10 hours 10 minutes, and with fares starting at just $181, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Philadelphia?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Compare bus companies
Based on 87516 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $189
Frequently asked questions about travelling from Des Moines to Philadelphia, PA by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Philadelphia?
The cheapest bus tickets from Des Moines to Philadelphia start from $181. The average price for this route is around $256. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Philadelphia?
The average bus travel time from Des Moines to Philadelphia is 1d 10h, covering a distance of 1562 km. The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Des Moines to Philadelphia route?
Several major bus companies operate on this route with 7 buses available per day.
What are the earliest and latest departure times for the bus from Des Moines to Philadelphia?
The earliest bus departs from Des Moines to Philadelphia at 9:25am. And the latest bus departs at 9:45am.
What are the CO₂ emissions for the bus trip from Des Moines to Philadelphia?
A bus trip from Des Moines to Philadelphia generates an estimated 39 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Philadelphia, PA was searched and found on Jan 23, 2026 with a price of $223To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Philadelphia, PA, as early as possible.
You can expect to pay from $223 to $366 for a bus ticket from Des Moines to Philadelphia, PA based on the last 2 days. You can expect to find the cheapest price for the trip at $223 which is on 2026-01-23.
