Bus Tickets from Boston, MA, US to Greenville, SC

Find affordable bus tickets from Boston, MA, US to Greenville, SC with flexible options. Book your trip now

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TodayAug 2
from US$163
TomorrowAug 3
from US$178
MonAug 4
TueAug 5
WedAug 6
from US$122
ThuAug 7
FriAug 8
SatAug 9

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: August 3 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 3 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 3 at
    Departure city: Boston
    Departure location: Brookline
    Arrival time: August 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 3 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 3 at
    Departure city: Boston
    Departure location: 151 Steel Pl, Cambridge
    Arrival time: August 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Today at 12:57 AM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Boston to Greenville

Bus
Average PriceUS$85 - US$281Average Duration23h 5m
32kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$197 - US$550Average Duration20h 56m
116kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Boston to Greenville

Among the sustainable travel choices, the train stands out as a good way to reach Greenville. The journey takes about 20 hours 56 minutes, and with fares starting at just US$197, it presents an excellent value for a comfortable ride.

3train per day
20h 56mAverage Duration
US$197Cheapest ticket
116kgCO₂ emissions

Bus Boston, MA, US to Greenville, SC: Trip Overview

Average Ticket PriceUS$134
Average Bus Trip Duration23h 5m
Number of daily buses8
Earliest bus departure1:30am
Distance1282 km
Latest bus departure10:00pm

Boston to Greenville Bus

Busbud helps you find a bus from Boston to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Boston to Greenville will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Boston, MA, US - Greenville, SC

  1. What is the travel distance from Boston to Greenville?

    It's about 1291 km (801 miles) from Boston to Greenville.

  2. What are the departure and arrival locations for buses traveling from Boston to Greenville?

    Buses departing from Back Bay Station in Boston will take you to Guadalajara Supermarket Bus Stop in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-31
No data
08-01
No data
Today
US$148
08-03
US$170
08-04
US$78
08-05
US$111
08-06
US$115
08-07
US$78
busbud logoThe cheapest trip from Boston, MA, US to Greenville, SC was searched and found on Aug 4, 2025 with a price of US$78

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Greenville, SC, as early as possible.

You can expect to pay from US$78 to US$209 for a bus ticket from Boston, MA, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$78 which is on 2025-08-04.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Boston and Greenville!

Much more than a mere vehicle taking you from Boston to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from Boston to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Boston, MA, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Boston, MA, US by bus?

Bus from Boston, MA, US to Greenville, SC

You can also go to Greenville, SC by train

Train from Boston, MA, US to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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